{"id":2321,"date":"2024-10-04T14:14:48","date_gmt":"2024-10-04T12:14:48","guid":{"rendered":"https:\/\/xinnate.com\/?page_id=2321"},"modified":"2024-11-03T22:07:38","modified_gmt":"2024-11-03T21:07:38","slug":"publications","status":"publish","type":"page","link":"https:\/\/xinnate.com\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;4&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-754354&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;580860&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column width=&#8221;1\/1&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/1&#8243;][vc_custom_heading separator_color=&#8221;yes&#8221; separator=&#8221;yes&#8221; uncode_shortcode_id=&#8221;165880&#8243;]Publications[\/vc_custom_heading][vc_column_text uncode_shortcode_id=&#8221;117478&#8243;]<\/p>\n<h4>Endotoxic shock and sepsis models<\/h4>\n<ul>\n<li>Kalle M, Papareddy P, Kasetty G, M\u00f6rgelin M, van der Plas M, Rydeng\u00e5rd V, Malmsten M, Albiger B, Schmidtchen A. Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and\u00a0<em>Pseudomonas aeruginosa<\/em>\u00a0sepsis. <strong>PLOS One, <\/strong>2012;7(12):e52772<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0051313\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Papareddy P, Rydeng\u00e5rd V, Pasupuleti M, Walse B, M\u00f6rgelin M, Chalupka A, Malmsten M, Schmidtchen A. Proteolysis of human thrombin generates novel host defense peptides. <strong>PLoS Pathog<\/strong>. 2010 Apr 22;6(4):e1000857<br \/>\n<a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1000857\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<\/ul>\n<h4>Biomaterials<\/h4>\n<ul>\n<li>Str\u00f6mdahl AC, Ignatowicz L, Petruk G, Butrym M, Wasserstrom S, Schmidtchen A, Puthia M. Peptide-coated polyurethane material reduces wound infection and inflammation. <strong>Acta Biomater.<\/strong> 2021 May 2:S1742-7061(21)00289-0. doi: 10.1016\/j.actbio.2021.04.045<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34010691\/\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Kasetty G, Kalle M, M\u00f6rgelin M, Brune JC, Schmidtchen A. Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides. <strong>Biomaterials,<\/strong> 2015, 53, 415e425<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961215002495\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<\/ul>\n<h4>Mode of action<\/h4>\n<ul>\n<li>Hansen FC, Nadeem A, Browning KL, Campana M, Schmidtchen A, van der Plas MJA. Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages. <strong>J Innate Immun<\/strong>. 2021 Dec 22:1-15. doi: 10.1159\/000520831. PMID: 34937021<br \/>\n<a href=\"https:\/\/www.karger.com\/Article\/FullText\/520831\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Dahlman A, Puthia M, Petrlova J, Schmidtchen A, Petruk G. Thrombin-Derived C-Terminal Peptide Reduces Candida-Induced Inflammation and Infection In Vitro and In Vivo. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0103221. doi: 10.1128\/AAC.01032-21. <strong>Epub<\/strong> 2021 Aug 23. PMID: 34424043; PMCID: PMC8522777<br \/>\n<a href=\"https:\/\/journals.asm.org\/doi\/full\/10.1128\/AAC.01032-21\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>\n<div class=\"highwire-cite-title media__headline__title\"><span class=\"highwire-citation-author\" data-delta=\"6\">Puthia M, Butrym M, Petrlova J, Str\u00f6mdahl AC, Andersson M\u00c5, Kjellstr\u00f6m S, Schmidtchen A. <\/span>A dual-action peptide-containing hydrogel targets wound infection and inflammation. <strong>Science Translational Medicine<\/strong>. 2020 Jan 01; \u00a012(524):eaax6601<br \/>\n<a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aax6601\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/div>\n<\/li>\n<li>Holdbrook DA, Huber RG, Marzinek JK, Stubbusch A, Schmidtchen A, Bond, PJ. Multiscale modeling of innate immune receptors: Endotoxin recognition and regulation by host defense peptides, <strong>Pharmacological Research<\/strong>, Volume 147, 2019, 104372, ISSN 1043-6618<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1043661819305742\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Holdbrook DA, Singh S, Choong YK, Petrlova J, Malmsten M, Bond PJ, Verma NK, Schmidtchen A, Saravanan R. Influence of pH on the activity of thrombin-derived antimicrobial peptides. <strong>Biochim Biophys Acta Biomembr.<\/strong> 2018 Nov;1860(11):2374-2384<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S000527361830172X\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Saravanan R, Holdbrook DA, Petrlova J, Singh S, Berglund NA, Choong YK, Kjellstr\u00f6m S, Bond PJ, Malmsten M, Schmidtchen A. Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides. <strong>Nature Communications<\/strong><em>.\u00a0<\/em>2018 Jul 17;9(1):2762<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-018-05242-0\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Lim CW, Puthia M, Butrym M, Tay TM, Lee M, Hou HW, Schmidtchen A. Thrombin-derived host defence peptide modulates neutrophil rolling and migration\u00a0<em>in vitro<\/em>\u00a0and functional response\u00a0<em>in vivo.\u00a0<\/em>2017, <strong>Sci Rep<\/strong>. 7, 11201<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-017-11464-x\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Hansen FC, Str\u00f6mdahl AC, M\u00f6rgelin M, Schmidtchen A, van der Plas M. Thrombin-derived host defense peptides modulate monocyte\/macrophage inflammatory responses to Gram-negative bacteria. <strong>Front. Immunol. <\/strong>2017 doi: 10.3389\/fimmu. 2017.00843<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2017.00843\/full\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Hansen F, Kalle-Brune M, van der Plas MJA, Str\u00f6mdahl AC, Malmsten M, M\u00f6rgelin M, Schmidtchen A. The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through interactions with lipopolysaccharide and macrophages\/monocytes. <strong>Journal of Immunology<\/strong>, 2015, 194:5397-5406<br \/>\n<a href=\"https:\/\/journals.aai.org\/jimmunol\/article\/194\/11\/5397\/98433\/The-Thrombin-Derived-Host-Defense-Peptide-GKY25?searchresult=1\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Singh S, Kalle M, Papareddy P, Schmidtchen A, Malmsten M. Lipopolysaccharide interactions of C-terminal peptides from human thrombin<strong>. Biomacromolecules.<\/strong> 2013 May 13;14(5):1482-92<br \/>\n<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/bm400150c\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<\/ul>\n<h4>Other related publications on BioC\u00a0or related variants<\/h4>\n<ul>\n<li>Puthia M, Tanner L, Petruk G, Schmidtchen A. Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin. <strong>ACS Pharmacology &amp; Translational Science\u00a0<\/strong>2022\u00a05\u00a0(3), 141-148 DOI: 10.1021\/acsptsci.1c00219<br \/>\n<a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acsptsci.1c00219\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Petruk G, Petrlova J, Samsudin F, Giudice RD, Bond PJ, Schmidtchen A. Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25. <strong>Biomolecules<\/strong>. 2020 Nov 19;10(11):1572. doi: 10.3390\/biom10111572<br \/>\n<a href=\"https:\/\/www.mdpi.com\/2218-273X\/10\/11\/1572\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Saravanan R, Adav SS, Choong YK, ven der Plas MJA, Kjellstr\u00f6m S, Sze SK, Schmidtchen A.\u00a0 Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid\u00a0<em>in vivo.\u00a0<\/em>2017, <strong>Sci Rep<\/strong>. 7, 13136<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-017-13197-3\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Petrlova P, Hansen FC, van der Plas MJA, Huber RG, M\u00f6rgelin M, Malmsten M, Bond P, and Schmidtchen A. Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism. <strong>Proceedings of the National Academy of Sciences<\/strong>, 2017. 114,E4213<br \/>\n<a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.1619609114\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>van der Plas M, Bhongir R, Kjellstr\u00f6m S, Siller H, Kasetty G, M\u00f6rgelin M, Schmidtchen A. Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses. 2016. <strong>Nature Communications, <\/strong>16;7:11567<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/ncomms11567\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Merza, M, Rahman M, Zhang S, Hwaiz R, Regner S, Schmidtchen A, Thorlacius H. Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue damage in severe acute pancreatitis. <strong>American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology, <\/strong>2014, 1;307(9):G914-21<br \/>\n<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpgi.00237.2014\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<li>Kasetty G, Papareddy P, Kalle M, Rydeng\u00e5rd V, M\u00f6rgelin M, Albiger B, Malmsten M, Schmidtchen A. Structure-activity studies and therapeutic potential of host defense peptides of human thrombin<strong>. Antimicrob Agents Chemother. <\/strong>2011 Jun;55(6):2880-90<br \/>\n<a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01515-10?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\" target=\"_blank\" rel=\"noopener\">View publication<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;4&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-754354&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;580860&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column width=&#8221;1\/1&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/1&#8243;][vc_custom_heading separator_color=&#8221;yes&#8221; separator=&#8221;yes&#8221; uncode_shortcode_id=&#8221;165880&#8243;]Publications[\/vc_custom_heading][vc_column_text uncode_shortcode_id=&#8221;117478&#8243;] [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/pages\/2321"}],"collection":[{"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/comments?post=2321"}],"version-history":[{"count":3,"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/pages\/2321\/revisions"}],"predecessor-version":[{"id":2413,"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/pages\/2321\/revisions\/2413"}],"wp:attachment":[{"href":"https:\/\/xinnate.com\/wp-json\/wp\/v2\/media?parent=2321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}