{"id":363,"date":"2019-10-09T14:54:24","date_gmt":"2019-10-09T12:54:24","guid":{"rendered":"https:\/\/xinnate.com\/?page_id=363"},"modified":"2022-10-28T12:45:38","modified_gmt":"2022-10-28T10:45:38","slug":"pre-clinical-results","status":"publish","type":"page","link":"https:\/\/xinnate.com\/pre-clinical-results\/","title":{"rendered":"Pre-clinical results"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;5&#8243; bottom_padding=&#8221;5&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;4&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;2&#8243; style=&#8221;light&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner][vc_column_inner column_width_percent=&#8221;56&#8243; position_horizontal=&#8221;left&#8221; gutter_size=&#8221;2&#8243; style=&#8221;light&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h3&#8243; text_size=&#8221;h1&#8243;]Pre-Clinical results[\/vc_custom_heading][vc_column_text]<\/p>\n<div class=\"heading-text el-text\">\n<div class=\"text-lead text-top-reduced\">\n<p>An extensive preclinical package including stability, metabolism, efficacy and initial toxicity has been finalized with excellent results. The BioC concept has been validated in relevant animal wound models of bacterial infection and inflammation and proven to be superior to widely used benchmarks containing PHMB or silver.<\/p>\n<\/div>\n<\/div>\n<div class=\"clear\">\n<p>The unique mode of action of BioC gives a multiple effect which discriminates BioC from other existing wound healing products:<\/p>\n<\/div>\n<p>[\/vc_column_text][vc_empty_space empty_h=&#8221;2&#8243; desktop_visibility=&#8221;yes&#8221;][\/vc_column_inner][\/vc_row_inner][vc_empty_space empty_h=&#8221;2&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;1&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading text_size=&#8221;h5&#8243; sub_reduced=&#8221;yes&#8221; uncode_shortcode_id=&#8221;145011&#8243;]Anti-infective[\/vc_custom_heading][vc_single_image media=&#8221;1321&#8243; media_width_percent=&#8221;70&#8243; media_ratio=&#8221;one-one&#8221; alignment=&#8221;center&#8221; shape=&#8221;img-circle&#8221;][vc_column_text uncode_shortcode_id=&#8221;450976&#8243;]For prevention and early treatment of infections. It is effective on both gram-positive and gram-negative bacteria and also on drug resistant bacteria.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;1&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;4&#8243; mobile_width=&#8221;4&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading text_size=&#8221;h5&#8243; sub_reduced=&#8221;yes&#8221;]Anti-inflammatory[\/vc_custom_heading][vc_single_image media=&#8221;1323&#8243; media_width_percent=&#8221;70&#8243; media_ratio=&#8221;one-one&#8221; alignment=&#8221;center&#8221; shape=&#8221;img-circle&#8221;][vc_column_text]Naturally managing the paradox keeping the initial healthy level of inflammation and quenching the excessive damaging systemic. No drug with a similar modulatory effect exists today.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;1&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;4&#8243; mobile_width=&#8221;4&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading text_size=&#8221;h5&#8243; sub_reduced=&#8221;yes&#8221;]Anticoagulative[\/vc_custom_heading][vc_single_image media=&#8221;1320&#8243; media_width_percent=&#8221;70&#8243; media_ratio=&#8221;one-one&#8221; alignment=&#8221;center&#8221; shape=&#8221;img-circle&#8221;][vc_column_text]By inhibiting local contact and tissue factor activation BioC reduces injury-induced harmful inflammation.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space empty_h=&#8221;3&#8243;][vc_row_inner][vc_column_inner column_width_percent=&#8221;66&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading]<b>Direct effects <\/b><b>of <\/b><b>BioC<\/b> <b>gel <\/b><b>on bacteria<\/b>[\/vc_custom_heading][vc_column_text]<b><i>In vitro<\/i><\/b> <b>antibacterial effects of <\/b><b>BioC<\/b><b> gel.<br \/>\n<\/b>Bioluminescent <i>S. aureus<\/i> or <i>P. aeruginosa<\/i> bacteria were incubated with BioC gel and the bioluminescent signal was analyzed using bioimaging (IVIS Spectrum).[\/vc_column_text][vc_single_image media=&#8221;1242&#8243; media_width_percent=&#8221;72&#8243; alignment=&#8221;center&#8221;][vc_empty_space empty_h=&#8221;2&#8243;][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner column_width_percent=&#8221;100&#8243; align_horizontal=&#8221;align_center&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading]<b>Effects <\/b><b>of <\/b><b>BioC<\/b> <b>gel in a <\/b><b>wound <\/b><b>model <\/b>[\/vc_custom_heading][vc_empty_space empty_h=&#8221;2&#8243;][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; equal_height=&#8221;yes&#8221; gutter_size=&#8221;4&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243;][vc_column_text]<b>BioC<\/b> <b>gel reduces infection in wounds. <\/b>Microbiological analysis of wounds from days 2, 3, and 4 of treatment.[\/vc_column_text][vc_single_image media=&#8221;1372&#8243; media_width_percent=&#8221;80&#8243;][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243;][vc_column_text]<b>BioC<\/b> <b>gel reduces <\/b><b>inflammation in wounds. <\/b>Analysis of wound fluid cytokines collected on days 2, 3, and 4 of treatment.[\/vc_column_text][vc_single_image media=&#8221;1374&#8243; media_width_percent=&#8221;80&#8243;][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243;][vc_column_text]<b>BioC<\/b> <b>gel improves wound healing.<br \/>\n<\/b>Clinical scoring of wounds after 3 days of treatment.[\/vc_column_text][vc_single_image media=&#8221;1373&#8243; 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