Endotoxic shock and sepsis models

  • Kalle M, Papareddy P, Kasetty G, Mörgelin M, van der Plas M, Rydengård V, Malmsten M, Albiger B, Schmidtchen A. Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. PLOS One, 2012;7(12):e52772
  • Papareddy P, Rydengård V, Pasupuleti M, Walse B, Mörgelin M, Chalupka A, Malmsten M, Schmidtchen A. Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog. 2010 Apr 22;6(4):e1000857


  • Strömdahl AC, Ignatowicz L, Petruk G, Butrym M, Wasserstrom S, Schmidtchen A, Puthia M. Peptide-coated polyurethane material reduces wound infection and inflammation. Acta Biomater. 2021 May 2:S1742-7061(21)00289-0. doi: 10.1016/j.actbio.2021.04.045
  • Kasetty G, Kalle M, Mörgelin M, Brune JC, Schmidtchen A. Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides. Biomaterials, 2015, 53, 415e425

Mode of action

  • Hansen FC, Nadeem A, Browning KL, Campana M, Schmidtchen A, van der Plas MJA. Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages. J Innate Immun. 2021 Dec 22:1-15. doi: 10.1159/000520831. PMID: 34937021
  • Dahlman A, Puthia M, Petrlova J, Schmidtchen A, Petruk G. Thrombin-Derived C-Terminal Peptide Reduces Candida-Induced Inflammation and Infection In Vitro and In Vivo. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0103221. doi: 10.1128/AAC.01032-21. Epub 2021 Aug 23. PMID: 34424043; PMCID: PMC8522777
  • Puthia M, Butrym M, Petrlova J, Strömdahl AC, Andersson MÅ, Kjellström S, Schmidtchen A. A dual-action peptide-containing hydrogel targets wound infection and inflammation. Science Translational Medicine. 2020 Jan 01;  12(524):eaax6601
  • Holdbrook DA, Huber RG, Marzinek JK, Stubbusch A, Schmidtchen A, Bond, PJ. Multiscale modeling of innate immune receptors: Endotoxin recognition and regulation by host defense peptides, Pharmacological Research, Volume 147, 2019, 104372, ISSN 1043-6618
  • Holdbrook DA, Singh S, Choong YK, Petrlova J, Malmsten M, Bond PJ, Verma NK, Schmidtchen A, Saravanan R. Influence of pH on the activity of thrombin-derived antimicrobial peptides. Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2374-2384
  • Saravanan R, Holdbrook DA, Petrlova J, Singh S, Berglund NA, Choong YK, Kjellström S, Bond PJ, Malmsten M, Schmidtchen A. Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides. Nature Communications2018 Jul 17;9(1):2762
  • Lim CW, Puthia M, Butrym M, Tay TM, Lee M, Hou HW, Schmidtchen A. Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo. 2017, Sci Rep. 7, 11201
  • Hansen FC, Strömdahl AC, Mörgelin M, Schmidtchen A, van der Plas M. Thrombin-derived host defense peptides modulate monocyte/macrophage inflammatory responses to Gram-negative bacteria. Front. Immunol. 2017 doi: 10.3389/fimmu. 2017.00843
  • Hansen F, Kalle-Brune M, van der Plas MJA, Strömdahl AC, Malmsten M, Mörgelin M, Schmidtchen A. The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through interactions with lipopolysaccharide and macrophages/monocytes. Journal of Immunology, 2015, 194:5397-5406
  • Singh S, Kalle M, Papareddy P, Schmidtchen A, Malmsten M. Lipopolysaccharide interactions of C-terminal peptides from human thrombin. Biomacromolecules. 2013 May 13;14(5):1482-92

Other related publications on BioC or related variants

  • Puthia M, Tanner L, Petruk G, Schmidtchen A. Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin. ACS Pharmacology & Translational Science 2022 5 (3), 141-148 DOI: 10.1021/acsptsci.1c00219
  • Petruk G, Petrlova J, Samsudin F, Giudice RD, Bond PJ, Schmidtchen A. Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25. Biomolecules. 2020 Nov 19;10(11):1572. doi: 10.3390/biom10111572.
  • Saravanan R, Adav SS, Choong YK, ven der Plas MJA, Kjellström S, Sze SK, Schmidtchen A.  Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo. 2017, Sci Rep. 7, 13136
  • Petrlova P, Hansen FC, van der Plas MJA, Huber RG, Mörgelin M, Malmsten M, Bond P, and Schmidtchen A. Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism. Proceedings of the National Academy of Sciences, 2017. 114,E4213
  • van der Plas M, Bhongir R, Kjellström S, Siller H, Kasetty G, Mörgelin M, Schmidtchen A. Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses. 2016. Nature Communications, 16;7:11567
  • Merza, M, Rahman M, Zhang S, Hwaiz R, Regner S, Schmidtchen A, Thorlacius H. Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue damage in severe acute pancreatitis. American Journal of Physiology – Gastrointestinal and Liver Physiology, 2014, 1;307(9):G914-21
  • Kasetty G, Papareddy P, Kalle M, Rydengård V, Mörgelin M, Albiger B, Malmsten M, Schmidtchen A. Structure-activity studies and therapeutic potential of host defense peptides of human thrombin. Antimicrob Agents Chemother. 2011 Jun;55(6):2880-90