Endotoxic shock and sepsis models

  • Kalle M, Papareddy P, Kasetty G, Mörgelin M, van der Plas M, Rydengård V, Malmsten M, Albiger B, Schmidtchen A. Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. PLOS One, 2012;7(12):e52772
  • Papareddy P, Rydengård V, Pasupuleti M, Walse B, Mörgelin M, Chalupka A, Malmsten M, Schmidtchen A. Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog. 2010 Apr 22;6(4):e1000857


  • Kasetty G, Kalle M, Mörgelin M, Brune JC, Schmidtchen A. Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides. Biomaterials, 2015, 53, 415e425

Mode of action

  • Puthia M, Butrym M, Petrlova J, Strömdahl AC, Andersson MÅ, Kjellström S, Schmidtchen A. A dual-action peptide-containing hydrogel targets wound infection and inflammation. Science Translational Medicine. 2020 Jan 01;  12(524):eaax6601
  • Saravanan R, Holdbrook DA, Petrlova J, Singh S, Berglund NA, Choong YK, Kjellström S, Bond PJ, Malmsten M, Schmidtchen A. Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides. Nature Communications2018 Jul 17;9(1):2762
  • Lim CW, Puthia M, Butrym M, Tay TM, Lee M, Hou HW, Schmidtchen A. Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo. 2017, Sci Rep. 7, 11201
  • Hansen FC, Strömdahl AC, Mörgelin M, Schmidtchen A, van der Plas M. Thrombin-derived host defense peptides modulate monocyte/macrophage inflammatory responses to Gram-negative bacteria. Front. Immunol. 2017 doi: 10.3389/fimmu. 2017.00843
  • Singh S, Kalle M, Papareddy P, Schmidtchen A, Malmsten M. Lipopolysaccharide interactions of C-terminal peptides from human thrombin. Biomacromolecules. 2013 May 13;14(5):1482-92
  • Hansen F, Kalle-Brune M, van der Plas MJA, Strömdahl AC, Malmsten M, Mörgelin M, Schmidtchen A. The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through interactions with lipopolysaccharide and macrophages/monocytes. Journal of Immunology, 2015, 194:5397-5406

Other related publications on BioC or related variants

  • Saravanan R, Adav SS, Choong YK, ven der Plas MJA, Kjellström S, Sze SK, Schmidtchen A.  Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo. 2017, Sci Rep. 7, 13136
  • Petrlova P, Hansen FC, van der Plas MJA, Huber RG, Mörgelin M, Malmsten M, Bond P, and Schmidtchen A. Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism. Proceedings of the National Academy of Sciences, 2017. 114,E4213
  • van der Plas M, Bhongir R, Kjellström S, Siller H, Kasetty G, Mörgelin M, Schmidtchen A. Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses. 2016. Nature Communications, 16;7:11567
  • Merza, M, Rahman M, Zhang S, Hwaiz R, Regner S, Schmidtchen A, Thorlacius H. Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue damage in severe acute pancreatitis. American Journal of Physiology – Gastrointestinal and Liver Physiology, 2014, 1;307(9):G914-21
  • Kasetty G, Papareddy P, Kalle M, Rydengård V, Mörgelin M, Albiger B, Malmsten M, Schmidtchen A. Structure-activity studies and therapeutic potential of host defense peptides of human thrombin. Antimicrob Agents Chemother. 2011 Jun;55(6):2880-90