Pre-Clinical results
An extensive preclinical package including stability, metabolism, efficacy and initial toxicity has been finalized with excellent results. The BioC concept has been validated in relevant animal wound models of bacterial infection and inflammation and proven to be superior to widely used benchmarks containing PHMB or silver.
The unique mode of action of BioC gives a multiple effect which discriminates BioC from other existing wound healing products:
Anti-infective
For prevention and early treatment of infections. It is effective on both gram-positive and gram-negative bacteria and also on drug resistant bacteria.
Anti-inflammatory
Naturally managing the paradox keeping the initial healthy level of inflammation and quenching the excessive damaging systemic. No drug with a similar modulatory effect exists today.
Anticoagulative
By inhibiting local contact and tissue factor activation BioC reduces injury-induced harmful inflammation.
Direct effects of BioC gel on bacteria
In vitro antibacterial effects of BioC gel.
Bioluminescent S. aureus or P. aeruginosa bacteria were incubated with BioC gel and the bioluminescent signal was analyzed using bioimaging (IVIS Spectrum).
Effects of BioC gel in a wound model
BioC gel reduces infection in wounds. Microbiological analysis of wounds from days 2, 3, and 4 of treatment.
BioC gel reduces inflammation in wounds. Analysis of wound fluid cytokines collected on days 2, 3, and 4 of treatment.
BioC gel improves wound healing.
Clinical scoring of wounds after 3 days of treatment.
Read more about: