The Unique Concept

The Xinnate concept is based on our patented BioC–platform, a peptide which is part of the human natural defence system. The mode of action is very well understood and published in high impact journals such as Nature Communications.  The uniqueness of the BioC based drug is threefold.


BioC has a broader biological effect than currently used drugs – it targets both inflammation and infection.


BioC is effective also on multiresistant bacteria, i.e. bacteria that are resistant to antibiotics. Because of its mode of action, BioC is unlikely to cause bacterial resistance, and can therefore potentially replace and reduce the use of antibiotics.


BioC is part of our own natural defence system and is therefore unlikely to be harmful for the patient or the environment. It therefore has a clear potential to replace and reduce the use of other substances with negative side effects.

A. Targeting infection and inflammation

Bacteria entering a wound cause localized infections. Moreover, bacteria and their endotoxins often cause excessive inflammation. In severe cases, bacteria can be released into the blood stream and released endotoxins can cause an excessive and sometimes lethal inflammatory response, i. e. sepsis.

Today´s treatments, targeting microbes with antibiotics, are only able to remove the invading bacteria, but they don’t address the inflammation. There is a great and unmet need for new innovative products that can both prevent infection and reduce inflammation.

Figure 1 – Illustration of the mode of action of BioC hydrogel. BioC in the hydrogel has a direct killing effect on bacteria. BioC scavenges endotoxins and binds to bacteria, leading to reduced inflammation but with retained bacterial and toxin clearance. Inflammation is therefore controlled.

Anti-infective – for prevention and early treatment of infections. It is effective on both gram-positive and gram-negative bacteria and also on drug resistant bacteria. Infection related diseases are causing millions of deaths and entails huge costs worldwide and this will increase

Anti-inflammatory – naturally managing the paradox keeping the initial healthy level of inflammation and quenching the excessive damaging systemic inflammation.

Inflammation is natural reaction during wound healing but in the presence of bacteria, bacterial endotoxins or other pro-inflammatory substances, uncontrolled and excessive inflammation can cause impaired wound healing and fibrosis (scarring). Therefore, targeting inflammation in combination with infection will decrease healing time and improve the cosmetic and functional end result.

No drug with a similar dual effect exists today, and this broad biological effect enables an extensive range of target indications in advanced wound care, such as burn wounds and surgical wounds, but also other applications such as post cosmetic treatment, surgical sutures and other biomaterials in skin contact (catheters, ostomy, skin replacement materials)

B. Replacing and reducing the use of antibiotics

Infections are typically prevented and treated with antibiotics. The excessive utilisation of antibiotics, however, has generated an increasing range of bacteria that are resistant. This means, that in the future there will be infections where antibiotics are not effective, and that we in the future will have to restrain the use of the remaining effective antibiotics to the most critical situations. The expected future limited efficiency and availability of antibiotics will mean that preventive care will become increasingly important – we therefore need more efficient and sustainable drugs that target wound infection and inflammation at an early stage.

C. Replacing and reducing the use of other anti-infective substances with negative side effects

Current topical wound treatments are based on anti-infective components (iodine, silver, PHMB). These substances are all, in different ways, potentially harmful for the environment and/or the patient. There is thus a need to replace the current use of antiseptics for wound treatments with more efficient alternatives without negative side effects.